
Introduction to Nattokinase
In the world of natural health supplements, few names spark as much interest as Nattokinase. This powerful enzyme, derived from the Japanese fermented soybean dish Natto, has been celebrated for centuries for its potential to support cardiovascular health and improve blood circulation. With modern science catching up to tradition, nattokinase is now studied globally for its role in heart health, clot prevention, and even cognitive support.
But what exactly makes nattokinase so special? And is it truly the miracle enzyme some claim it to be? Let’s break it down step by step.
What is Nattokinase?
Nattokinase is a fibrinolytic enzyme, meaning it helps break down fibrin, a protein involved in blood clot formation. This natural enzyme is created during the fermentation process of soybeans with the bacteria Bacillus subtilis. Unlike many other supplements, nattokinase is not artificially manufactured but is derived from a traditional Japanese superfood that has been consumed for more than 1,000 years.
The History of Nattokinase in Traditional Japanese Medicine
Natto has been a staple in Japan since at least the 11th century, often consumed for its supposed ability to promote longevity and vitality. Locals noticed that regular natto eaters seemed to enjoy better cardiovascular health. In the 1980s, Dr. Hiroyuki Sumi, a Japanese researcher, isolated the nattokinase enzyme, confirming scientifically what tradition had long suggested.
How Nattokinase is Produced

The production of nattokinase involves:
- Steaming soybeans until soft.
- Fermenting them with Bacillus subtilis bacteria.
- Enzyme extraction and purification to create supplements in capsule or powder form.
This natural fermentation process is what gives nattokinase its unique blood-thinning properties.
Health Benefits of Nattokinase
Cardiovascular Health Support
One of the most recognized benefits of nattokinase is its ability to support heart health. Studies suggest it helps reduce blood pressure, lower cholesterol, and improve overall circulation.
Blood Clot Prevention and Circulation
Because nattokinase breaks down fibrin, it may help prevent the formation of dangerous blood clots. This could reduce the risk of stroke, heart attack, and deep vein thrombosis (DVT).
Anti-inflammatory Properties
Chronic inflammation contributes to heart disease and other health conditions. Nattokinase may help lower inflammation markers, promoting overall wellness.
Potential Role in Immune Support
Some research suggests nattokinase could enhance immune system function by improving blood flow and nutrient delivery to tissues.
Cognitive and Neurological Benefits
Improved circulation may also benefit the brain, potentially reducing risks of vascular dementia and enhancing mental clarity.
Nattokinase vs. Other Enzymes
Nattokinase vs. Serrapeptase
Both are enzymes with anti-inflammatory effects, but serrapeptase is derived from silkworms, while nattokinase comes from soybeans. Nattokinase is more closely linked to cardiovascular support.
Nattokinase vs. Bromelain
Bromelain, from pineapples, is often used for digestion and swelling, while nattokinase is specifically prized for blood clot breakdown.
Scientific Research on Nattokinase
Clinical Studies and Findings
Recent studies highlight nattokinase’s role in lowering blood pressure, enhancing circulation, and possibly reducing stroke risk.
Ongoing Research and Future Potential
Scientists continue to explore nattokinase for conditions like Alzheimer’s disease, chronic fatigue, and immune health.
Dosage and Supplementation
Recommended Daily Dosage
Most research suggests 100–200 mg per day (about 2,000–4,000 fibrinolytic units).
Best Time to Take Nattokinase
Experts recommend taking it on an empty stomach for maximum absorption.
Forms: Capsules, Powders, and Fermented Soy
- Capsules: Most common and convenient.
- Powder: Can be mixed into drinks.
- Traditional Natto: Strong taste, but a natural source.
Safety, Side Effects, and Risks
Who Should Avoid Nattokinase
- People are taking blood thinners like warfarin.
- Those with bleeding disorders.
- Pregnant or breastfeeding women.
Possible Drug Interactions
Nattokinase may interact with aspirin, heparin, and other anticoagulants.
Safe Usage Guidelines
Always consult a healthcare professional before starting supplementation.
Buying Guide: Choosing the Right Nattokinase Supplement
What to Look for in a High-Quality Supplement
- Third-party testing
- Non-GMO soy
- Standardized enzyme activity
Trusted Brands and Sources
Stick with brands known for transparency and purity. For example, Examine.com offers evidence-based supplement guidance.
Storage and Shelf Life
Keep supplements in a cool, dry place, away from direct sunlight.
Frequently Asked Questions (FAQs)
1. Is nattokinase safe for daily use?
Yes, but only under recommended dosage and with medical guidance.
2. Can nattokinase replace blood thinners?
No, it should not replace prescribed medications unless advised by a doctor.
3. How long does it take to see benefits?
Some users report improvements in 2–4 weeks, depending on health goals.
4. Can I get enough nattokinase from eating natto?
Yes, but you’d need to eat large amounts daily—supplements are more practical.
5. Does nattokinase lower blood pressure?
Studies suggest it can help reduce systolic and diastolic blood pressure.
6. Are there vegan nattokinase supplements?
Yes, since it’s derived from fermented soy, most supplements are naturally vegan.
Conclusion: Should You Try Nattokinase in 2025?
Nattokinase stands as a promising natural supplement for cardiovascular health, circulation, and overall wellness. While not a replacement for prescribed medications, it can be a powerful addition to a healthy lifestyle when taken responsibly.
As research expands, nattokinase may prove even more valuable for future generations. For now, if you’re looking for a natural way to support heart and brain health, nattokinase is worth considering—just be sure to consult your doctor before starting.
Disclaimer: This information is not intended to be medical advice. If you have any questions or need more details on a particular aspect of the above topic, please ask your doctor!



